系统性红斑狼患者感染的免疫特征变化
Langxian Zhi1, Liyang Gu1, Lei Tong2
1Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200001, China.
Clinical and experimental medicine
|November 8, 2023
概括
感染扩大了系统性红斑狼 (SLE) 患者的免疫变化,增加了中性粒细胞CD64 (nCD64) 表达,髓质衍生抑制细胞 (MDSC) 和激活的T细胞. 在SLE感染期间观察到 IL-6,IL-8和IL-10细胞因子的升高.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,其特征是免疫调节失调.
- 感染是SLE患者患病和死亡的重要原因之一.
- 了解SLE感染期间的免疫状态对于患者管理至关重要.
研究的目的:
- 为了研究患有感染的SLE患者的免疫状态.
- 分析临床特征和免疫学参数,包括中性粒细胞CD64 (nCD64) 表达,骨髓原抑制细胞 (MDSC),激活的T细胞和细胞因子.
主要方法:
- 253名SLE患者的横截面研究,其中77人患有活跃感染.
- 对临床数据,nCD64表达,MDSCs (总数,PMN-MDSCs,M-MDSCs),激活的T细胞 (CD4+CD38+,CD8+HLA-DR+,CD8+CD38+) 和血清细胞因子 (IL-6,IL-8,IL-10) 的分析.
主要成果:
- 患有感染的SLE患者的发烧和血清炎的发病率较高.
- 在感染组中显著增加了nCD64表达,总MDSC,PMN-MDSC和M-MDSC.
- 在感染SLE患者中观察到T细胞 (CD4+CD38+,CD8+HLA-DR+,CD8+CD38+) 的激活增加以及IL-6,IL-8和IL-10的血清水平升高.
结论:
- 感染加剧了SLE患者的免疫失调.
- 增加的nCD64,MDSCs,激活的T细胞和促炎细胞因子 (IL-6,IL-8,IL-10) 标志着SLE感染的免疫反应.
- 这些发现凸显了在SLE感染期间放大了免疫变化.
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