氧化平衡得分与美国成年人结石患病率之间的关系
Gaoteng Lin1, Fangfang Zhan2,3, Jinxin Zhu4
1Department of Urology, The 900th Hospital of Joint Logistic Support Force, Fuzhou, China.
International urology and nephrology
|November 8, 2023
概括
较高的氧化平衡得分 (OBS) 与结石 (KS) 的风险降低有关. 这项研究表明,OBS可以成为评估结石风险的重要指标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 结石 (KS) 是一个严重的健康负担.
- 氧化压力在各种慢性疾病中起作用.
- 氧化平衡得分 (OBS) 和KS患病率之间的关系需要进一步研究.
研究的目的:
- 评估氧化平衡得分 (OBS) 与结石 (KS) 患病率之间的关联.
- 为了确定OBS是否可以作为结石风险的预测指标.
主要方法:
- 从2007年到2018年进行的国家健康和营养检查调查 (NHANES) 的数据分析.
- 使用加权调整后勤回归来评估KS和OBS之间的关联.
- 使用受限制的立方线来检查KS和OBS之间的剂量反应关系.
主要成果:
- 对于每增加一个单位的OBS (OR=0.97,P=0.01) 来说,KS风险下降了3%.
- 较高的OBS四分位数显示,与最低四分位数相比,KS患病率的风险显著降低 (Q3与Q1:OR=0.7,P=0.04;Q4与Q1:OR=0.66,P=0.04).
- 在OBS和KS风险之间检测出了线性关联,表明了一致的保护作用.
结论:
- 这项研究表明,OBS与患结石的风险之间存在显著的负面关系.
- OBS反映了个人的氧化压力负担,是评估结石风险的有价值指标.
- 研究结果支持生活方式修改的潜力,以改善OBS和减轻KS的发展.
相关概念视频
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
11
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
11
01:30Urinary Tract Calculi III: Medical Management
9
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
9
01:28Urinary Tract Calculi I: Introduction
16
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
16
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
13
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
13
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
18
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
18
01:28Urinary Tract Calculi V: Nursing Management
12
AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
12