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微细胞对加密球菌脑膜炎没有保护作用.

Sally H Mohamed1, Man Shun Fu1, Sofia Hain1

  • 1Institute of Immunology & Immunotherapy, University of Birmingham, Birmingham, UK.

Nature communications
|November 8, 2023
PubMed
概括

微质枯竭并没有阻碍真菌脑膜炎的控制. 相反,Cryptococcus neoformans在微质细胞中存活下来,这表明这些细胞可能充当早期感染储存器.

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Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...