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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
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Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

1.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.4K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

753
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
753
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

68.6K
Overview
68.6K
T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Updated: Jul 11, 2025

Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells
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Measurement of Natural Killer Cell-Mediated Cytotoxicity and Migration in the Context of Hepatic Tumor Cells

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泰米斯2调节了自然杀手细胞的记忆功能和形成.

Tsukasa Nabekura1,2,3, Elfira Amalia Deborah4,5, Saeko Tahara4,6,7

  • 1Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Ibaraki, 305-8575, Japan. nabekura.tsukasa.fe@u.tsukuba.ac.jp.

Nature communications
|November 8, 2023
PubMed
概括

支架蛋白Themis2调节了自然杀手 (NK) 细胞的记忆力. 泰米斯2缺乏增强了记忆NK细胞的形成和对老鼠细胞巨乳病毒 (MCMV) 感染的宿主保护.

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Two Flow Cytometric Approaches of NKG2D Ligand Surface Detection to Distinguish Stem Cells from Bulk Subpopulations in Acute Myeloid Leukemia
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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 传染性疾病 传染性疾病

背景情况:

  • 免疫记忆是适应性免疫的一个关键特征.
  • 自然杀手 (NK) 细胞对于天生的防御至关重要,可以发展成为记忆NK细胞.
  • 控制记忆NK细胞分化的分子通路仍然不完全理解.

研究的目的:

  • 确定记忆NK细胞分化和功能的关键调节者.
  • 阐明脚手架蛋白Themis2在NK细胞记忆中的作用.
  • 调查NK细胞记忆的Themis2介导调节背后的分子机制.

主要方法:

  • 在体外和体内对Themis2缺乏NK细胞的分析.
  • 评估NK细胞分化和效应器功能的评估.
  • 研究涉及Ly49H,ZAP70/Syk和Zfp740.0的信号通路.
  • 鼠类细胞巨乳病毒 (MCMV) 感染模型.

主要成果:

  • 泰米斯2缺乏导致记忆NK细胞的分化增强.
  • 缺乏Themis2的NK细胞提供了对MCMV感染的增强保护.
  • 泰米斯2通过减弱ZAP70/Syk酸化来抑制Ly49H信号传递.
  • 泰米斯2与核中的Zfp740相互作用,调节记忆NK细胞的持久性.

结论:

  • 米斯2是NK细胞记忆形成的定量和质量的关键调节者.
  • Themis2-Zfp740通路对于控制记忆NK细胞的持久性和功能非常重要.
  • 准Themis2可能为调节基于NK细胞的免疫提供新的策略.