发生精神分裂症和出生窒息的胎盘基因组风险对大脑发育的影响
Laura A Wortinger1,2, Alexey A Shadrin3,4,5, Attila Szabo3,4,5
1Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway. l.a.w.bakke@medisin.uio.no.
Translational psychiatry
|November 8, 2023
概括
出生窒息和胎盘遗传风险因素与精神分裂症 (SZ) 有关. 较高的胎盘遗传风险得分与出生窒息相结合,与男性头部尺寸较小相关,影响大脑发育和SZ脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
背景情况:
- 胎盘对于胎儿大脑发育至关重要.
- 怀孕和分娩并发症,如出生窒息,可以表明胎盘功能障碍,并与精神分裂症 (SZ) 相关.
- 胎盘遗传风险因素与出生窒息对大脑发育的影响之间的关系尚不清楚.
研究的目的:
- 为了调查胎盘遗传风险因素SZ和出生窒息之间的联系.
- 检查这些因素如何影响大脑发育,特别是新生儿头周长 (nHC) 和成人内体积 (ICV).
主要方法:
- 利用了433名成年SZ患者和870名对照组的数据.
- 从挪威的医疗出生登记处获得的怀孕和出生数据.
- 计算了胎盘多原风险评分 (PlacPRS) 并使用多重回归分析了与出生窒息的相互作用,包括nHC和ICV.
主要成果:
- 在有出生窒息史的人群中,胎盘PRS与SZ的更高可能性有关.
- 在PlacPRS和出生窒息之间发现了显著的相互作用,显示较高的PlacPRS与出生窒息患者的较低nHC有关.
- 这种影响是男性特有的,也观察到成年ICV.
结论:
- 胎盘功能障碍和出生窒息可能会对大脑发育轨迹产生负面影响,特别是在男性中.
- 研究结果表明,潜在的途径将胎盘因素,分娩并发症和男性对SZ的脆弱性联系起来.
- 这项研究可能会为新的精神分裂症预防和治疗策略提供信息.
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