在印尼人口中对COVID-19后认知失败的疾病严重程度和外部因素的纵向研究
Bumi Herman1,2, Martin Chi Sang Wong3,4,5,6,7, Prawat Chantharit8
1College of Public Health Sciences, Chulalongkorn University, Bangkok, Thailand.
Scientific reports
|November 8, 2023
概括
感染COVID-19可能会导致认知衰竭,受疾病严重程度以外的因素的影响. 疫苗接种状态,年龄,疲劳和焦虑显著影响感染后的认知功能.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 认知衰竭是COVID-19感染的潜在长期后果之一.
- 了解COVID-19,疫苗接种,药物和非COVID-19因素对认知健康的相互作用至关重要.
研究的目的:
- 调查COVID-19感染,疫苗接种情况和药物对认知衰竭的影响之间的关系.
- 为了确定非COVID-19相关的因素,有助于感染后的认知衰退.
主要方法:
- 印尼的一项队列研究 (2021年9月至2023年1月) 评估了人口统计,临床,并发症,疫苗接种和药物数据.
- 在6个月内使用认知失败问卷 (CFQ),疲劳严重性得分和GAD-7评估认知功能.
- 一个结构方程模型分析了认知失败的预测因素.
主要成果:
- 认知衰竭 (CFQ平均得分45.6 ± 23.1) 是多因素的,不仅仅取决于COVID-19的严重程度.
- 疾病严重程度与疫苗接种状况,年龄,先前感染和治疗单位有关,但与认知衰竭没有直接关系.
- 最糟糕的疫苗接种状态对认知衰竭有显著的直接影响 (p < 0.001).
- 年龄,疲劳和当前焦虑与较高的认知衰竭有显著的关联 (p < 0.001).
结论:
- 在COVID-19之后的认知衰竭是一个复杂的疾病,受到多种因素的影响.
- 长期疫苗和药物疗效需要进一步研究.
- 非健康相关的因素在COVID-19后的认知障碍中发挥着重要作用.
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