来自莫桑比克和美国的儿童的病原体负载较高,通过比较便微生物组概况揭示了这一点
Minjae Kim1,2, Luis M Rodriguez-R3, Janet K Hatt1
1School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
ISME communications
|November 8, 2023
概括
低收入国家的儿童具有独特的肠道微生物组,与高收入国家的儿童相比,其病原体负载更高. 环境因素,如卫生设施,显著影响婴儿肠道微生物组的发展和健康结果.
科学领域:
- 微生物组研究 微生物组研究
- 儿科健康 儿科健康
- 环境健康 环境健康
背景情况:
- 婴儿肠道微生物组对于终身健康和免疫是至关重要的.
- 关于低收入和中等收入国家 (LMICs) 与高收入国家 (HICs) 儿童之间的微生物组差异的数据有限.
研究的目的:
- 为了比较城市LMIC (马普托,莫桑比克) 和HIC (美国亚特兰大) 环境中的幼儿的肠道微生物组概况.
- 识别微生物组成,抗生素耐药性基因 (ARG) 和毒性因子 (VF) 的差异.
主要方法:
- 快枪元基因组学被用来分析48个月以下儿童的肠道微生物组.
- 在两个地理位置之间比较微生物多样性,ARG和VF的丰富性以及特定的细菌物种.
主要成果:
- 与Maputo相比,亚特兰大儿童在婴儿期后表现出更高的α多样性.
- 微生物组根据地理和年龄分别聚集在一起,表明了不同的发育轨迹.
- 马普托儿童的ARG和VF显著更高,肠毒性 (ETEC) 和肠病原性 (EPEC) 大肠杆菌的患病率高.
- 像Focaeicola vulgatus和Bacteroides caccae这样的食用物种在亚特兰大更为丰富.
结论:
- 环境因素,包括水,卫生和卫生 (WASH),显著塑造了儿科肠道微生物组.
- 肠道微生物群的差异可能与不同的病原体负载和对疾病的易感性有关.
- 在LMIC和HIC的城市环境对正在发展的婴儿肠道微生物组施加了不同的签名.
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