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皮肤微生物组的变化与移植受体的状细胞癌相关
Annika Krueger1, Julian Zaugg2, Nancy Lachner2
1The University of Queensland Diamantina Institute, Faculty of Medicine, University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.
ISME communications
|November 8, 2023
概括
皮肤微生物组在免疫受损和免疫能力较强的个体中,在动作性角质瘤 (AK) 和状细胞癌 (SCC) 之间存在差异. 有SCC的移植受体显示出Staphylococcus epidermidis的占主导地位,与有S. aureus.免疫能力的受体不同.
科学领域:
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 行动性角质瘤 (AK) 和状细胞癌 (SCC) 是常见的皮肤疾病,特别是在肤浅的人群中.
- 免疫抑制的个体,如器官移植接受者,面临着显著增加SCC发展的风险.
- 之前的研究指出,在免疫能力强的个体的AK/SCC病变中,黄金葡萄球菌过度生长,但免疫抑制队伍中的微生物组仍未被检查.
研究的目的:
- 研究和比较免疫抑制器官移植受体和先前研究的免疫能力较强队列之间的皮肤微生物组形状和细菌负载在动作性角质炎 (AK) 和状细胞癌 (SCC) 病变.
- 在免疫抑制个体中确定与AK和SCC相关的特定微生物差异.
主要方法:
- 32名免疫抑制器官移植接受者与AK,SCC和对照皮肤的皮肤拭子中的微生物概况和细菌负载的表征.
- 利用SSU rRNA基因测序和定量聚合酶链反应 (qPCR) 进行微生物分析.
- 结果与以前描述的免疫能力较强队列的数据进行了比较.
主要成果:
- 虽然皮肤微生物组的组成在很大程度上取决于个体,但在免疫抑制和免疫能力强的组中,在对照皮肤,AK和SCC之间发现了显著的差异.
- 与对照皮肤相比,在AK和SCC中观察到细菌负载增加和α多样性减少,这是由于Staphylococcus物种的丰富性和开始性细菌的减少.
- 来自移植受体的SCC病变主要由Staphylococcus epidermidis殖民,与来自免疫能力强的人的SCC上Staphylococcus aureus的主导地位形成鲜明对比.
结论:
- 行动性角质瘤和状细胞癌在免疫抑制和免疫能力强的个体中表现出明显的微生物失调.
- 这些微生物组的变化可能在SCC的发病和进展中发挥作用,在免疫抑制和免疫能力强的队列之间观察到特定的差异.
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