在双相情感障碍中,神经应激抵抗能力受损和REST丧失

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Updated: Jul 11, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

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Katharina Meyer1, King-Hwa Ling1, Pei-Ling Yeo1

  • 1Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.

Molecular psychiatry
|November 8, 2023
PubMed
概括

这项研究引入了双相情感障碍 (BD) 的人类大脑器官模型,揭示了受损的细胞应激反应和与REST基因相关的神经发育变化. 这些发现表明了理解BD病变的新框架.

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