在98,458名参与者中,饮食中的安托西亚尼丁与胆道癌症风险之间的关联:来自前性研究的结果
Ling Xiang1,2, Dabin Wu1, Zhiquan Xu1
1Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China.
概括
饮食中使用的安托西亚尼丁可以降低胆道癌症的风险. 这项研究发现,在美国成年人中,高摄入量的安东基亚尼丁与胆道癌的发病率较低有关.
科学领域:
- 在瘤学瘤学.
- 营养流行病学 营养流行病学
- 预防癌症 预防癌症
背景情况:
- 安东基亚尼丁和富含安东基亚尼丁的食物显示出对各种癌症的潜在保护作用.
- 饮食中含有的安托西亚尼丁与胆道癌症风险之间的特定联系尚未得到充分证实.
研究的目的:
- 为了研究饮食中总摄入的安托西亚尼丁与患上胆汁癌症的风险之间的关联.
- 探索剂量-反应关系和这种关联中的潜在改变因素.
主要方法:
- 利用了前列腺,肺,结肠直肠和卵巢癌查试验的数据.
- 采用考克斯回归分析,对混因子进行调整,以估计危险比率 (HR) 和95%置信区间 (CI).
- 应用受限立方线模型进行剂量反应分析,并进行子组/敏感性分析.
主要成果:
- 在8.9年的随访期间观察到95例胆道癌症病例 (发病率:11每10万人年).
- 较高的安托西亚尼丁总摄入量与胆道癌症风险相反相关 (HR Q4与Q1:0.52;95%CI:0.29-0.91;Ptrend =0.043).
- 确定了线性剂量-反应关系和与饮酒状态的显著相互作用.
结论:
- 这项研究提供了证据,支持总安托西亚尼丁摄入量与胆道癌症发病率之间的反向关联.
- 富含安东基亚尼丁的饮食可能有助于减少特定成年人群的胆管癌症风险.
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