医疗保险受益人与行动性角质瘤的皮肤癌
Cassandra Mohr1, Yao Li1, Lucy J Navsaria1
1Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston.
JAMA dermatology
|November 8, 2023
概括
患有行动性角质瘤 (AKs) 的患者面临患各种皮肤癌的风险显著增加,包括状细胞癌 (SCC),基底细胞癌 (BCC) 和黑色素瘤. 这凸显了对AKS患者改善皮肤癌监测指南的必要性.
科学领域:
- 皮肤病学 皮肤病学
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 行动性角质瘤 (AKs) 是一种常见的前恶性皮肤病变.
- 患有AK的患者患其他皮肤癌的风险较高,但绝对风险尚未确定.
研究的目的:
- 在被诊断为AKs的Medicare受益人中确定未来皮肤癌的绝对和相对风险.
主要方法:
- 从2009年至2018年,对近500万名医疗保险受益人的回顾性队列研究.
- 包括接受治疗的AKs患者和患有斑块性角质瘤 (SKs) 的比较组.
- 排除以前有皮肤癌病史的患者;分析随后手术治疗的皮肤癌.
主要成果:
- 在第一次AK诊断后,任何皮肤癌的绝对风险在5年内为28.5%.
- 与SK相比,AK患者的皮肤癌风险显著增加 (例如,SCC aHR为2.63,黑色素瘤 aHR为1.67).
结论:
- 患有AK的老年人具有大量的皮肤癌的绝对和相对风险.
- AKs可以作为累积紫外线暴露和增加皮肤癌易感性的指标.
- 对于AKs患者的皮肤癌监测有必要制定基于证据的指导方针.
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