在百万退伍军人计划队列中,无抑制行为的风险相关性
Peter B Barr1,2,3,4, Tim B Bigdeli1,2,3,4, Jacquelyn L Meyers1,2,3,4
1VA New York Harbor Healthcare System, Brooklyn.
JAMA psychiatry
|November 8, 2023
概括
外向化 (EXT) 障碍与其他精神问题有着共同的遗传基础,并影响退伍军人的健康. 这项研究发现EXT多基因风险评分 (PGS) 与退伍军人的物质使用障碍和相关健康问题有关.
科学领域:
- 精神病学遗传学 精神病学遗传学
- 退伍军人健康 退伍军人的健康
- 基因组流行病学 基因组流行病学
背景情况:
- 外向化 (EXT) 障碍,以行为失禁为特征,与精神病的结果有关.
- 全基因组关联研究 (GWAS) 揭示了EXT疾病和退伍军人健康问题 (如自杀和物质使用障碍) 之间的重叠.
研究的目的:
- 在退伍军人卫生管理局 (VA) 百万退伍军人计划 (MVP) 中调查EXT疾病风险的遗传相关性.
- 探索EXT多基因风险评分 (PGS) 与大型退伍军人队列中的各种健康结果之间的关联.
主要方法:
- 对EXT PGS的全现象关联研究 (PheWAS) 通过使用电子健康记录在不同祖先中进行.
- 进行了条件和家庭内分析,以评估与其他精神疾病的独立性,并为混因素进行调整.
主要成果:
- EXT PGS与619个结局有关,其中188个独立于其他精神病风险.
- 在非洲,欧洲和西班牙裔/拉丁美洲祖先之间观察到显著的关联.
- 家庭内分析证实了EXT PGS和SUD后果之间的联系,例如肝病和病毒性C型肝炎.
结论:
- 对于EXT疾病存在一个共享的多基因基础,独立于其他精神疾病.
- EXT PGS与SUD及其后续相关,突出了美国退伍军人的潜在健康后果.
- 这项研究强调了EXT障碍对退伍军人的健康和功能的影响.
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