一个可穿戴设备,用于自动检测和治疗阿片类药物过量服用
IEEE transactions on biomedical circuits and systems
|November 8, 2023
概括
一个新的可穿戴设备使用近红外光谱 (NIRS) 传感器通过监测氧气水平来检测阿片类药物过量. 它可以在检测缺氧事件后的10秒内自动输送纳洛,一种阿片类药物对手,可能挽救生命.
科学领域:
- 生物医学工程 生物医学工程
- 可穿戴技术可穿戴技术
- 毒理学 毒理学 毒理学
背景情况:
- 在美国,阿片类药物过量是导致死亡的主要原因,2021年有超过8万例死亡.
- 纳洛是一种阿片类药物对手,可以逆转阿片类药物诱导的呼吸抑制.
- 需要一个闭环系统,用于自动检测过量剂量和纳洛输送.
研究的目的:
- 开发和测试一个便携式,手腕穿戴,闭环可穿戴设备,用于检测和应对阿片类药物过量事件.
- 创建一个工程解决方案,以减轻阿片类药物流行病的影响.
主要方法:
- 设计了一个手腕穿戴设备,集成近红外光谱 (NIRS) 传感器,MOSFET开关和零电压切换 (ZVS) 电磁加热器.
- 支臂动脉封闭 (BAO) 用于8名人类受试者来模拟缺氧驱动的阿片类药物过量事件.
- 评估了该设备检测低氧化和触发药物释放的能力.
主要成果:
- 在BAO期间,在人类受试者身上表现出一致的低氧化事件.
- 该设备成功检测了低氧事件,并在10秒内释放了药物.
- 在低氧化事件之前和之后 (p < 0.001) 观察到氧血球,脱氧血球和氧和 (SpO2) 水平的显著差异.
结论:
- 开发的可穿戴设备显示承诺作为一种工具来检测基于缺氧的阿片类药物过量事件.
- 该系统的快速药物输送能力是实现自动闭环过量反应的关键一步.
- 需要进一步对人类进行实验,但初步结果表明,有可能减轻阿片类药物流行病的影响.
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