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Updated: Aug 14, 2026

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将衰老细胞模型的转录组与多组织患者样本的整合揭示了降低的COL6A3作为衰老的诱导剂

Radoslav Savić1, Jialiang Yang1, Simon Koplev2

  • 1Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA.

Cell reports
|November 8, 2023
PubMed
概括

细胞衰老有助于衰老的心血管问题. 这项研究确定了新的生物标志物和与衰老相关的分泌表型 (SASP) 因素,如COL6A3,为组织特定的衰老机制提供了洞察力.

关键词:
在 COL6A3A3 中.CP: 细胞生物学 细胞生物学细胞衰老 细胞衰老原蛋白是一种原蛋白.疾病 疾病 疾病 疾病人类 人类 人类 人类 人类 人类 人类整合 整合 整合 整合网络 网络 网络 网络 网络 网络文字转录 字体转录 字体转录

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...