高度大麻产品对健康的影响:范围审查和证据地图
Lisa Bero1, Rosa Lawrence1, Jean-Pierre Oberste1
1Lisa Bero and Rosa Lawrence are with the Department of General Internal Medicine, Center for Bioethics and Humanities, University of Colorado, Anschutz Medical Campus, Aurora. Jean-Pierre Oberste, Tianjing Li, Louis Leslie, and Tsz Wing Yim are with Department of Ophthalmology, University of Colorado, Anschutz Medical Campus. Thanitsara Rittiphairoj is with Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD. Christi Piper is with Strauss Health Sciences Library, University of Colorado, Anschutz Medical Campus. George Sam Wang is with Department of Pediatrics, Children's Hospital Colorado, University of Colorado, Anschutz Medical Campus. Ashley Brooks-Russell is with Department of Community and Behavioral Health, Colorado School of Public Health, University of Colorado, Anschutz Medical Campus. Gregory Tung is with Department of Epidemiology, Colorado School of Public Health, University of Colorado, Anschutz Medical Campus. Jonathan M. Samet is with Office of the Dean, Colorado School of Public Health, University of Colorado, Anschutz Medical Campus.
高度大麻产品越来越普遍,但对其健康影响的证据有限. 这次审查发现,缺乏高质量的数据,可以为调节四大麻素 (THC) 水平的政策提供信息.
科学领域:
- 公共卫生 公共卫生
- 大麻研究 大麻研究
- 卫生政策 卫生政策
背景情况:
- 大麻产品呈现出高度的四大麻醇 (THC).
- 由于对潜在的不良健康影响的担忧,需要对THC度限制进行政策考虑.
- 进行了范围审查,以评估有关高THC大麻和健康结果的现有研究.
研究的目的:
- 确定和描述研究高度大麻产品与健康结果之间的关系的人类研究.
- 创建一个交互式的证据地图包括的研究进一步分析和决策.
主要方法:
- 对7个电子数据库进行了全面的搜索.
- 包括任何报告THC度或高THC产品的流行病学设计的人类研究.
- 使用人工智能辅助的选和数据抽象,高级审核员验证.
主要成果:
- 452项研究被纳入了范围审查和证据地图.
- 暴露特征 (THC度,使用模式) 的报告不完整.
- 在研究设计,暴露,结果和人群中观察到显著的异质性,限制了定量合成.
结论:
- 目前的文献对于描述当代高THC大麻产品的风险和益处具有有限的相关性.
- 很少有高质量的证据来为监管大麻产品THC度的政策提供信息.
- 提供了一个交互式证据地图,作为公共卫生实体的资源,以解决增加获得高THC大麻的问题的问题.
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