在患有帕金森病的患者中,跌倒和非运动性症状之间的关联
Zhen Li1, Xu Jiang1, Minggang Yang2
1Department of Geriatric Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
概括
跌倒在帕金森病 (PD) 患者中很常见. 非运动症状,如抑郁症和尿道问题显著增加跌倒的风险,与运动下降.
科学领域:
- 神经科学是一个神经科学.
- 老年病的医生 老年病的医生
- 运动障碍 运动障碍
背景情况:
- 帕金森病 (PD) 是一种进展性神经退行性疾病.
- 跌倒是PD的常见和严重并发症,导致严重的残疾和死亡率.
- 患PD症状和跌倒机制之间的确切关系仍然不完全理解.
研究的目的:
- 调查帕金森病患者中跌倒和非运动症状之间的关联.
- 确定特定的非运动性症状,这些症状可以作为PD下降的风险因素.
主要方法:
- 分析了361名帕金森病患者的队列.
- 在前六个月内记录下来.
- 使用验证的调查问卷评估非运动症状,包括NMS Quest,PDSS,HAMD,HAMA和MoCA.
主要成果:
- 17.5%的患者在过去六个月内跌倒.
- 摔倒者比较老,运动症状更严重,糖尿病患病率更高.
- 非运动性症状 (PD-NMS),抑郁症 (HAMD) 和焦虑症 (HAMA) 的得分增加与跌倒有关,而认知功能 (MoCA) 没有显著差异.
结论:
- 跌倒在PD中很普遍,并且与运动和非运动症状有关.
- 患PD的关键风险因素包括尿路症状,体位低血压,抑郁症和与HAMD相关的认知障碍.
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