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在意大利北部COVID-19首次爆发期间缺血性中风的性别差异

Davide Sangalli¹, Maurizio Versino², Irene Colombo³

¹Neurological Department, "Alessandro Manzoni" Hospital, ASST, Lecco, Via dell'Eremo 9/11, 23900 Lecco, Italy.

Journal of the neurological sciences

|November 8, 2023

概括

COVID-19大流行严重影响了缺血性中风的结果,在死亡率和治疗需求方面观察到显著的基于性别的差异. 进一步的性别特定分析对于管理SARS-CoV-2阳性中风患者至关重要.

科学领域:

神经学神经学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

COVID-19 流行病与缺血性中风患者的较差结果有关.
关于SARS-CoV-2阳性缺血性中风患者的性别特异性结果的数据有限.

研究的目的:

在COVID-19大流行期间,研究在缺血性中风患者中神经学并发症和结果的性别差异.
分析男性和女性SARS-CoV-2阳性缺血性中风患者之间的人口,临床和治疗差异.

主要方法:

进行了一项多中心,回顾性,观察性研究,涉及812名在2020年3月1日至4月30日期间入院的缺血性中风患者.
收集和比较人口统计特征,临床特征,治疗方法和结果的数据,重点关注性别差异.
意大利北部的20个神经病学单位参与招募患者,其中129名患者的SARS-CoV-2检测结果呈阳性.

主要成果:

与女性 (27.9%) 相比,男性COVID-19患者 (35.3%) 的住院死亡率更高.
阳性SARS-CoV-2患者的中风发生频率较高,病因不明,尤其是女性 (36.1%).
男性COVID-19患者更可能需要先进的呼吸支持 (cPAP,内管) 和再输血策略,并且CRP和D-二次体水平更高.

结论:

在COVID-19的缺血性中风患者的临床表现,治疗和结果中存在显著的基于性别的差异.
这些发现强调了性别特定分析对于优化SARS-CoV-2阳性中风患者的临床管理的重要性.

关键词:

在 COVID-19 疫情中,缺血性中风是因为缺血性中风.这就是SARS-CoV-2病毒.性差异性差异性差异性差异性差异性差异性差异性

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