膝关节骨关节炎与死亡率之间的关联:连续倾向得分匹配的队列研究
Minkyung Oh1, Mi-Yeong Kim2, Min Wook So3
1Department of Pharmacology, Inje University College of Medicine, Busan, Korea.
The Korean journal of internal medicine
|November 8, 2023
概括
症状性膝关节关节炎与韩国人的心血管疾病死亡率增加有关. 倾向性得分匹配显示出较弱的关联,这表明膝关节关节炎和死亡率的风险估计更加精确.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 类风湿病学 类风湿病学
背景情况:
- 症状性膝关节骨关节炎 (OA) 和心血管疾病 (CVD) 死亡率之间确立的关联.
- 之前的研究受限于代谢风险因素的混.
- 需要精确估计OA对死亡率的影响.
研究的目的:
- 通过倾向性得分匹配来评估膝关节OA和死亡率之间的关联.
- 为了控制OA与死亡率关系中的代谢风险因素.
- 在韩国人口中提供膝关节OA的精确死亡风险估计.
主要方法:
- 使用韩国国家健康和营养检查调查 (2010-2013) 数据的队列研究.
- 将调查数据与韩国统计局的死亡原因数据联系起来 (截至2019年).
- 倾向性得分匹配 (1:1) 和考克斯比例危险建模.
主要成果:
- 症状性膝关节骨质炎显示心血管疾病死亡率较高 (HR 1.39; 95% CI 0.89-2.17).
- 没有发现无症状的OA或膝盖疼痛与心血管疾病死亡率有显著的关联.
- 没有观察到膝关节OA与任何原因或癌症死亡率之间的关联.
结论:
- 倾向性得分匹配降低了症状膝关节OA和心血管疾病死亡率之间的明显关联.
- 这些发现提供了对韩国人膝关节OA总死亡风险的更精确估计.
- 症状性膝关节骨质炎仍然是心血管疾病死亡的潜在风险因素.
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