免疫血栓和补充激活有助于疾病严重性和COVID-19的不良结果
Tiphaine Ruggeri1,2, Yasmin De Wit3, Noëlia Schärz1,2
1Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, Bern, Switzerland.
Journal of innate immunity
|November 8, 2023
概括
严重的COVID-19涉及全身炎症和血栓形成. 补充和中性粒细胞激活驱动微血管问题,像无细胞DNA和D-二次体这样的标记物表明疾病的严重程度和死亡率.
科学领域:
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
- 生物标志物 生物标志物
背景情况:
- 严重的COVID-19与全身炎症和多器官功能障碍综合征 (MODS) 有关.
- COVID-19中的微血管并发症是由补体和中性粒细胞激活引起的,包括中性粒细胞外细胞陷.
- 动脉和静脉血栓形成导致COVID-19患者的MODS和死亡.
研究的目的:
- 调查中性粒细胞和补充激活在COVID-19病变发生过程中的作用.
- 确定可靠的生物标志物来确定COVID-19疾病严重程度和死亡率.
- 评估这些生物标志物的治疗干预监测潜力.
主要方法:
- 分析了来自83名COVID-19患者的长度血和血清样本.
- 测量包括无细胞DNA,中性粒细胞激活,脱氧核糖核酶I活性,补体激活和D-二次体.
- 在入学时,11日和28日,在不同疾病严重程度的患者中收集了样本.
主要成果:
- 包括无细胞DNA,中性粒细胞激活,补体激活和D-二次体在内的标记物随着COVID-19疾病严重程度的增加而增加.
- 严重的COVID-19显示持续的中性粒细胞和补体激活,D-二次体形成和核细胞释放.
- 轻度和中度的COVID-19病例随着时间的推移,这些标记物呈现下降.
结论:
- 中性粒细胞和补体激活是COVID-19中微血管并发症和免疫血栓形成的关键驱动因素.
- 无细胞DNA,中性粒细胞激活,补体激活和D-二次体水平是COVID-19严重程度和死亡率的潜在生物标志物.
- 这些生物标志物可能有助于评估COVID-19治疗的疗效.
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