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生活必需品8和慢性病之间的年龄相关相互作用:国家横截面分析
Yuan Zhang1, Ning Ning2, Xiaoting Fan1
1Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China.
Preventive medicine
|November 8, 2023
概括
使用Life's Essential 8 (LE8) 改善心血管健康与降低慢性病 (CKD) 风险有关. 这种关联在老年人中更强烈,突出了CVH对不同年龄组脏健康的重要性.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 公共卫生 公共卫生
背景情况:
- 慢性病 (CKD) 是一种与年龄相关的严重疾病,通常与心血管疾病同时发生.
- 心血管健康 (CVH) 对整体健康和疾病预防至关重要.
研究的目的:
- 调查美国人口中生命必需8 (LE8) 和CKD之间的年龄依赖关系.
- 了解通过LE8测量的CVH如何与不同年龄组的CKD相互作用.
主要方法:
- 利用了25529名参与国家健康和营养检查调查 (2007-2018) 的数据.
- 采用多变量逻辑回归和受限立方线回归来分析LE8和CKD关联以及剂量反应关系.
- 研究了LE8和CKD之间的年龄相关相互作用.
主要成果:
- 较高的LE8得分与较低的CKD风险显著相关 (OR:0.71;95%CI:0.67,0.75).
- 在LE8和CKD之间观察到非线性剂量反应关系.
- 与年轻年龄组相比,65岁及以上的个体中LE8对CKD的保护性关联性更为明显 (相互作用P = 0.002).
结论:
- 根据LE8的评估,心血管健康与CKD存在显著的反向关系.
- 这种关联是非线性的,在老年人 (≥65岁) 中特别强烈,这表明针对这一人口群的有针对性的干预措施.
- 通过LE8指标促进最佳的CVH可能是预防和管理CKD的关键策略,特别是在老年人群中.
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