在体外受精结果的邻居贫困和种族差异
Kerri E Andre1, Robert B Hood2, Audrey J Gaskins2
1Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA.
American journal of obstetrics and gynecology
|November 8, 2023
概括
在体外受精 (IVF) 结果中存在种族差异. 虽然社区贫困与种族有关,但在本研究中,它没有显著影响试管婴儿周期取消,流产或活产率.
科学领域:
- 生殖医学 生殖医学
- 公共卫生 公共卫生
- 健康的社会经济决定因素
背景情况:
- 在体外受精 (IVF) 结果中存在显著的种族差异,这些差异无法通过个人因素充分解释.
- 环境影响,如邻居的社会经济地位,可能会在这些差异中发挥作用.
- 很少有大型研究研究了社区特征对不同人群IVF结果的直接影响.
研究的目的:
- 检查邻居贫困和体外受精 (IVF) 结果之间的关联.
- 确定社区贫困是否影响周期取消,流产或活产率.
- 评估这些跨不同种族群体的关联.
主要方法:
- 对1110名接受2254次自主试管婴儿周期 (2014-2019) 的患者进行了回顾性队列研究.
- 社区贫困指数 (NDI) 用于衡量社区层面的社会经济因素 (贫困,职业,住房,教育).
- 多变量日志双项通用估计方程通过NDI分析了循环取消,流产和活产的风险,并按种族分层.
主要成果:
- 增加NDI与更高的体重指数和输卵管/子宫不孕症的患病率相关.
- 与白人患者相比,黑人患者的原始活产率较低 (24%) 和原始流产率较高 (22%),分别为32%和12%.
- 经过调整后的分析显示,NDI和试管婴儿周期取消或活产风险之间没有显著的关联;结果在种族层面上一致.
结论:
- 在黑人和白人女性之间IVF后流产和活产率的种族差异得到证实.
- 邻里贫困,尽管与种族相关,但在这个群体中,它并没有成为试管婴儿结果的重要独立预测因素.
- 需要进一步的研究,以充分阐明导致在生育治疗成功的种族差异的复杂因素.
相关概念视频
01:52Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
01:23Behavioral Genetics and Its Designs
381
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
381
01:24In Vitro Fertilization
301
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
301
01:23Infertility in Males
275
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
275
01:25Genetic Variation
297
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
Genes exist in different versions called alleles,...
297
02:07Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K