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Updated: Jul 11, 2025

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对22种必需和非必需氨基酸的生物变异估计的性别相关差异
Abdurrahman Coşkun1, Anna Carobene2, Ozlem Demirelce3
1Acibadem Mehmet Ali Aydınlar University, School of Medicine, Department of Medical Biochemistry, Atasehir, Istanbul, Turkey; Acibadem Labmed Clinical Laboratories, Atasehir, Istanbul, Turkey; EFLM Working Group on Biological Variation, Milan, Italy; EFLM Task Group for the Biological Variation Database, Milan, Italy.
Clinica chimica acta; international journal of clinical chemistry
|November 8, 2023
概括
对22种氨基酸 (AAs) 的生物变异数据进行了分析,揭示了大多数AAs的受试者内部变异性 (CVI) 的显著性别差异. 这些发现影响了AA测量的临床解释.
科学领域:
- 临床化学 临床化学
- 生物标记分析 生物标记分析
- 人体生理学 人体生理学
背景情况:
- 血清氨基酸 (AA) 测量对于诊断和监测代谢的先天性错误至关重要.
- 可靠的生物变异 (BV) 数据对于准确的临床解释AA度至关重要.
- 了解AA BV的基于性别的差异对于个性化医学很重要.
研究的目的:
- 为了获得22种非必需,条件必需和必需氨基酸 (AAs) 的生物变异 (BV) 数据.
- 评估这些AA的生物变异的性别特异性差异.
主要方法:
- 在10周内,每周从66名受试者 (31名男性,35名女性) 收集血液样本.
- 使用液体染色学-并联质谱学分析样品.
- 在数据的统计评估后,估计的在主体内 (CVI) 和在主体之间 (CVG) BV.
主要成果:
- 在人体内,CVI估计从9.0% (histidine,男性) 到33.0% (taurine,男性) 不同.
- 对于大多数AAs,男性和女性之间CVI的显著差异被观察到,通常在女性中更高.
- 对大多数AAs,除了氨酸外,受试者之间的CVG估计在性别之间是相似的.
结论:
- 这项研究为22个AA提供了最新的BV估计.
- 大多数AA表现出体内生物变异的性别特异性差异 (CVI).
- 这些发现对AA测量的临床解释和应用有重大影响.
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