Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

13.0K
The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
13.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Comparison of the siRNA and mRNA Carrying Capacity of Quaternary Ammonium β-Cyclodextrin Polymer and Polyethylenimine.

Pharmaceutics·2026
Same author

Editorial: Molecular modeling in drug repurposing.

Frontiers in molecular biosciences·2026
Same author

Phototherapeutic β-Cyclodextrin-Branched Polymer Releasing Nitric Oxide with Fluorescent Self-Reporting and Its Combination with Doxorubicin.

Biomacromolecules·2026
Same author

CD44-targeted cyclodextrin-hyaluronic acid nanoparticles carrying gemcitabine and paclitaxel to pancreatic cancer.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026
Same author

Newly customized cationic ẞ-cyclodextrins as potential nanovectors for gene delivery.

International journal of pharmaceutics·2026
Same author

Emerging role of 7-Ketocholesterol and hydroxylated 7-Ketocholesterol in the pathophysiology of disease.

The Journal of steroid biochemistry and molecular biology·2026
Same journal

The rheological behavior, particle properties and supramolecular structure of low acyl gellan gum fluid gels: impact of the calcium concentration before fluid gel formation.

Carbohydrate polymers·2026
Same journal

Tuning the degree of substitution of octenyl succinic anhydride-modified highly branched cyclodextrin: Impacts on structure, physicochemical properties and emulsifying performance.

Carbohydrate polymers·2026
Same journal

Tailoring cellulose nanofibril separator networks with lignin for sustainable energy storage.

Carbohydrate polymers·2026
Same journal

Dual-functional synergistic modification of cellulose with phosphate and amidoxime for high-efficiency uranium capture in acidic wastewater.

Carbohydrate polymers·2026
Same journal

Hierarchical construction of a superhydrophobic and superior intrinsically flame-retardant phosphorylated microcrystalline cellulose bio-based composite aerogel.

Carbohydrate polymers·2026
Same journal

Structural characterization, in vitro anticoagulant, and antiplatelet activities of a Distolasterias nipon dermatan sulfate-like polymer with a distinctive sulfation pattern.

Carbohydrate polymers·2026
查看所有相关文章

相关实验视频

Updated: Jul 11, 2025

Use of Microscale Thermophoresis to Measure Protein-Lipid Interactions
04:45

Use of Microscale Thermophoresis to Measure Protein-Lipid Interactions

Published on: February 10, 2022

7.0K

解决测量循环德素-胆固醇结合常数的复杂性:一项多维研究

Amelia M Anderson1, Ilse Manet2, Milo Malanga3

  • 1Cyclarity Therapeutics, 8001 Redwood Blvd Novato, CA 94945, USA; Departamento de Física Aplicada, Facultade de Física, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain; Departamento de Química Orgánica, Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Universidade de Santiago de Compostela, Campus Vida s/n, E-15782 Santiago de Compostela, Spain.

Carbohydrate polymers
|November 8, 2023
PubMed
概括
此摘要是机器生成的。

循环德克斯二元体显示出通过结合氧醇治疗动脉样硬化的前景. 这些二元体对7-基托胆固醇的结合亲和力明显强于胆固醇,有助于减少斑块.

关键词:
亲和力常数是一种亲和力常数.一个圆形的二重化.循环德克斯特林 (Cyclodextrin) 是一种循环德克斯特林.包容性复杂的包容性复杂的异热量定位热量计 异热量定位热量计超动力学模拟的模拟.

更多相关视频

Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity
08:45

Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity

Published on: September 7, 2011

52.9K
Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method
09:38

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method

Published on: December 1, 2015

15.0K

相关实验视频

Last Updated: Jul 11, 2025

Use of Microscale Thermophoresis to Measure Protein-Lipid Interactions
04:45

Use of Microscale Thermophoresis to Measure Protein-Lipid Interactions

Published on: February 10, 2022

7.0K
Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity
08:45

Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity

Published on: September 7, 2011

52.9K
Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method
09:38

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer SALB Method

Published on: December 1, 2015

15.0K

科学领域:

  • 生物化学 生物化学
  • 超分子化学 超分子化学
  • 药用化学 医学化学

背景情况:

  • 动脉样硬化症的治疗可能涉及循环德素 (CD) 二次体,与氧醇形成复合体.
  • 鉴定这些CD-胆固醇相互作用是具有挑战性的,因为溶解度低和复杂的结合机制.

研究的目的:

  • 为了全面描述循环德林的二聚体-氧醇相互作用.
  • 用直角方法量化结合常数和阐明相互作用机制.

主要方法:

  • 超动力学模拟的模拟.
  • 竞争性异热定位热量计竞争性异热定位热量计
  • 圆形二重化谱光学 圆形二重化谱光学

主要成果:

  • 实现了CD二分体-氧化醇相互作用的全面表征.
  • 使用三个独立的技术量化结合常量.
  • 表明CD二元对7-基托胆固醇的亲和力大约是CD二元对1: 1复合体中的胆固醇的1000倍.

结论:

  • 开发并应用了强大的方法来研究具有挑战性的宿主-客系统.
  • 这些发现有助于更好地理解与动脉样硬化相关的CD二聚体-胆固醇相互作用.
  • 这些方法可能适用于其他复杂的主机-客户系统.