乙酸盐和酸盐对宿主肌肉能量有好处,因为它们是运动相关的后生物质
Ahmed Ismaeel1,2, Taylor R Valentino3, Benjamin Burke1,2
1Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Physiological reports
|November 8, 2023
概括
运动训练改变了肠道微生物组,增加了像Muribaculaceae这样的特定细菌. 这些细菌的代谢物乙酸和酸增强了骨肌肉的线粒体呼吸,可能改善了运动适应能力.
科学领域:
- 微生物学 微生物学
- 运动生理学 运动生理学
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物组影响运动适应.
- 一个肠道微生物群-骨肌肉轴建立.
- 运动训练诱导肠道微生物组成的变化.
研究的目的:
- 为了识别肠道微生物组的运动诱导的变化.
- 研究微生物代谢物在肌肉适应中的作用.
- 探索酸盐和酸盐对肌肉缩和新陈代谢的影响.
主要方法:
- 从训练有素和未训练有素小鼠的便样本进行元基因组学测序.
- 细菌生长的计算模拟,以预测代谢物.
- 在机械超负荷诱导的肌肉缩期间给小鼠服用酸盐和酸盐.
主要成果:
- 运动训练改变了肠道微生物群的β多样性,但没有α多样性.
- Muribaculaceae细菌DSM 103720的水平随着运动而增加.
- 乙酸盐和酸盐的使用增加了骨肌肉的线粒体呼吸.
- 在高的最初5天内,没有观察到整体肌肉生长的显著差异.
结论:
- 运动训练可以重塑肠道微生物组.
- 穆里巴库拉菌种的细菌产生酸盐和酸盐.
- 乙酸和酸盐可以改善氧化代谢在肌肉缩时,当作为后生物药物.
更多相关视频
10:23Characterizing Mediated Extracellular Electron Transfer in Lactic Acid Bacteria with a Three-Electrode, Two-Chamber Bioelectrochemical System
Published on: August 23, 2024
846
08:01Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
Published on: May 16, 2021
5.9K
相关概念视频
Muscle Recovery and Fatigue
2.1K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.1K
Fates of Pyruvate
8.5K
Pyruvate is the end product of glycolysis, where glucose is oxidized to pyruvate, simultaneously reducing NAD+ to NADH. Two molecules of ATP are also produced by substrate-level phosphorylation.
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
8.5K
The Citric Acid Cycle
151.8K
The citric acid cycle, also known as the Krebs cycle or TCA cycle, consists of several energy-generating reactions that yield one ATP molecule, three NADH molecules, one FADH2 molecule, and two CO2 molecules.
151.8K
Respiration Pathways
19
Cellular respiration is a fundamental metabolic process that enables organisms to generate energy from organic molecules. One of its central pathways is the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, which plays a crucial role in energy production and biosynthetic processes.Conversion of Pyruvate to Acetyl-CoAThe pyruvate generated from glycolysis undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex, producing acetyl-CoA, one molecule of NADH, and one...
19
Energy Supply for Muscle Contraction
3.2K
Skeletal muscle fibers have the unique ability to switch between rest and contraction states, using different sources of ATP for energy. The contraction cycle and Ca2+ transport back into the sarcoplasmic reticulum for relaxation require significant ATP. However, the ATP reserves in muscle fibers are limited and can only sustain contractions for a few seconds. Additional ATP production becomes necessary for prolonged contractions. As a result, muscle fibers generate ATP through various sources,...
3.2K
Amino Acid Catabolism
28
Microorganisms rely on proteins as an essential carbon and energy source, particularly in environments with limited polysaccharides or lipids. However, proteins are too large to cross the plasma membrane unaided, necessitating enzymatic degradation. Microbes secrete extracellular proteases and peptidases that hydrolyze proteins into peptides, which can then be transported across the membrane. Once inside the cell, intracellular proteases degrade these peptides into free amino acids, which...
28
