晚年成年人的循环时间,黑激素和海马体积
Chooza Moon1, Karin F Hoth2, Yelena Perkhounkova1
1University of Iowa College of Nursing, Iowa, Iowa, USA.
Journal of sleep research
|November 8, 2023
概括
较早的昼夜时间,以昏暗的光线表示黑激素的出现,以及较低的黑激素水平与老年人海马体积的减少有关. 这表明昼夜健康和大脑衰老之间存在联系.
科学领域:
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
- 老年学是指老年学的学科.
背景情况:
- 海马缩是阿尔茨海默病和相关痴呆症的一个关键特征.
- 循环节律障碍可能会加剧认知衰老和神经退行.
研究的目的:
- 研究昏暗光黑激素发作 (DLMO) 和黑激素水平与健康老年人海马体积之间的关联.
- 为了探索昼夜定时和老化中的大脑结构之间的关系.
主要方法:
- 利用3.0TMRI收集52名老年人的T1加权解剖图像 (平均年龄为70.0岁).
- 通过昏暗光黑激素发作 (DLMO) 评估昼夜时间,并在睡前6小时使用曲线下的面积 (AUC) 量化黑激素水平.
- 用于习惯性睡觉时间和多重线性回归的手腕动图,根据年龄和性别进行调整,以海马体积作为结果.
主要成果:
- 晚期的DLMO (b=0.16,p=0.005) 和睡前更高的黑激素AUC (b=0.05,p=0.046) 与更大的调整后的海马体积显著相关.
- 从DLMO到睡眠中点的时间和海马体积之间没有发现任何关联.
- 研究结果表明,较早的昼夜时间和降低的黑激素可能与降低的海马体积相关.
结论:
- 较早的昼夜定时 (DLMO) 和较低的黑激素水平与健康老年人的海马体体积减少有关.
- 这些发现凸显了昼夜节律调节在缓解大脑衰老中的潜在作用.
- 未来的研究可以利用昼夜节律数据来开发延迟与年龄相关的认知衰退的策略.
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