探索新生儿中生长失败的新生儿与肠静脉.
Joseph R Davidson1, Kareem Omran2, Clara K L Chong3
1Department of Paediatric Surgery, Evelina London Children's Hospital, London, UK; Stem Cells and Regenerative Medicine Section, GOS-UCL Institute of Child Health, London, UK; Prenatal Cell and Gene Therapy, Elizabeth Garrett Anderson UCL Institute for Women's Health, London, UK.
Journal of pediatric surgery
|November 8, 2023
概括
新生儿肠静脉切除术患者经历更频繁和严重的尿血 (催化作用的迹象) 显示出更严重的生长失败. 由C-反应蛋白 (CRP) 表示的炎症通常与尿素障碍相吻合,突出显示其在生长障碍中的作用.
科学领域:
- 新生儿手术 新生儿手术
- 儿科胃肠病学 儿科胃肠病学
- 生物化学 生物化学
背景情况:
- 新生儿肠静脉修复与显著的生长失败有关.
- 炎症过程可能会导致这些患者的催化状态.
研究的目的:
- 为了研究血清生物化学,炎症标志物和新生儿肠静脉切开术的婴儿的生长轨迹之间的关系.
- 为了确定炎症发作是否会导致触媒状态影响生长.
主要方法:
- 79名患有死性肠球炎 (NEC) 的婴儿进行了肠静脉切除术后期分析.
- 在口腔形成和关闭之间计算体重与年龄之间的Z分数变化 (ΔZ).
- 监测血清C反应蛋白 (CRP),尿素和肌素水平,计算曲线下的面积 (AUC) 长时间.
- 使用斯皮尔曼和多变量线性回归分析生物标志物趋势和与 ΔZ 的相关性.
主要成果:
- 在尿素AUC和ΔZ之间发现了显著的负相关性 (p=0.022),表明尿素含量较高,增长较差.
- 生物标志物峰值 (尿素和CRP) 的频率增加与 ΔZ 的下降显著相关 (p≤0.025).
- 多个生物标志物的同时出现的峰值始终与负 ΔZ (p≤0.016) 相关.
结论:
- 患有更严重生长衰竭的婴儿表现出更频繁和严重的尿血,这表明他们处于代谢状态.
- 尿素干扰经常与CRP升高相吻合,这意味着炎症是生长失败的关键因素.
- 研究结果支持积极的败血症管理,并建议更早地关闭口腔,以尽量减少风险期.
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