放射治疗和垂体腺瘤的死亡率
Baldomero González-Virla1, Guadalupe Vargas-Ortega1, Carlos Alfonso Romero-Gameros2
1Endocrinology Service, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Archives of medical research
|November 8, 2023
概括
对垂体腺瘤 (PA) 的放射治疗可以增加死亡风险,特别是心血管死亡,由于诱导的低垂体和脑血管疾病. 现代技术旨在减轻这些风险.
科学领域:
- 神经瘤学神经瘤学
- 内分泌学 在内分泌学.
- 辐射瘤学 辐射瘤学
背景情况:
- 垂体腺瘤 (PA) 是由功能和大小分类的内瘤,引起机械症状或荷尔蒙过分分泌.
- 治疗方案包括手术,治疗前乳腺瘤的药物治疗和辅助放射治疗 (RT).
- 整形外科的方法包括传统的,立体性放射性外科手术 (SRS) 和分成型立体性放射性外科手术 (FSRT),每一种都有潜在的并发症,如垂体下垂体和视神经炎.
研究的目的:
- 描述与放射治疗相关的死亡率信息,用于治疗功能性垂体腺瘤.
主要方法:
- 使用PubMed进行了文献搜索,搜索2000年至2017年间发表的文章,重点是脑下垂体放射治疗.
主要成果:
- 不同的RT方式 (传统,SRS,FSRT) 是根据瘤特征和接近关键结构而选择的.
- 虽然SRS和FSRT在瘤和内分泌控制方面表现出有效性,但RT与增加的死亡率有关,特别是心血管死亡率,特别是心肺下垂体和脑血管疾病的心血管死亡率.
- 由RT引起的损伤归因于微血管和动脉的变化.
结论:
- 现代技术技术正在提高安全性,但需要进行长期研究.
- 多学科评估对于优化治疗疗效和最小化风险至关重要.
- 改善患者的生活质量仍然是垂体腺瘤管理的关键目标.
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