长效微粒子配方的格里索富尔文用于眼部新血管化疗法治疗
Dhawal Chobisa1,2, Anbukkarasi Muniyandi3, Kamakshi Sishtla3
1Department of Industrial and Molecular Pharmaceutics, Purdue University, 575 West Stadium Avenue, West Lafayette, IN, 47907, USA.
Small (Weinheim an der Bergstrasse, Germany)
|November 8, 2023
概括
一种新的灰色富尔 (GRF) 微粒疗法显示出治疗新血管与年龄相关的黄斑变性 (nAMD) 的前景. 这种持续的眼部药物递送在临床前模型中有效抑制胆道新血管化 (CNV).
科学领域:
- 眼科医生 眼科 眼科
- 生物材料科学 生物材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 是老年人视力丧失的主要原因.
- 目前的抗血管内皮生长因子疗法对显著的患者小组是无效的.
- 铁甲基酶抑制为nAMD提供了潜在的治疗途径.
研究的目的:
- 开发和评估灰色 (GRF) 装载的聚乳酸合糖化物 (PLGA) 微粒 (MPs) 用于持续的视窗内输送.
- 评估GRFMPs在nAMD治疗中的体外和体外抗血管效果.
主要方法:
- GRF被封装到PLGAMPs中,并添加氧化以持续释放.
- 在体外研究中评估了对视网膜内皮细胞的抗血管性作用.
- 在体内有效性使用激光诱导的胆道新血管化 (CNV) 鼠标模型进行了评估.
主要成果:
- 在实验室中,GRF MPs显示药物持续释放 (>30天).
- 释放的GRF和GRFMP在细胞培养物中表现出显著的抗血管性质.
- 单次内注射GRFMPs有效抑制了老鼠在6周以上的时间内激光诱导的CNV.
结论:
- 内GRF装载的PLGAMPs提供有效的,持续的传递,以抑制CNV.
- 这种配方为一种新的,潜在的成本效益高的治疗策略提供了概念验证.
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