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开发一种新的F标记的小分子探针,用于中细胞上皮质过渡受体表达的PET成像

Lihong Bu^1,2, Xiaowei Ma³, Aiyan Ji^4,5

¹PET-CT/MRI Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

European journal of nuclear medicine and molecular imaging

|November 8, 2023

概括

一个新的PET探针,[18F]-AZC,允许在瘤中对c-Met表达的非侵入性可视化. 这种工具可以通过克服瘤异质性挑战来帮助管理抗c-Met疗法.

科学领域:

在瘤学瘤学.
放射化学放射化学是指辐射化学.
分子成像学分子成像学

背景情况:

介质细胞上皮转变因子 (c-Met) 是一个有效的抗癌标,但其表达异质性使抗c-Met疗法复杂化.
需要使用非侵入性工具来定量评估全身c-Met表达.

研究的目的:

开发和评估一种新的18F标记的PET探头[18F]-AZC,用于可视化c-Met表达.
在临床前质瘤模型中评估探针的有效性.

主要方法:

[18F]-AZC进行了合成和表征. 通过细胞吸收试验证实了特异性和亲和力.
进行了MicroPET/CT成像和生物分布研究,这些研究是针对皮下和正体质瘤外移植的.
与MRI和自发射线共注册,以及免疫光染色,用于验证.

主要成果:

[18F]-AZC表现出易于放射合成,高体外/体内稳定性,以及有利的物理化学特性,包括大脑运输.
该探针在注射后1小时内有效地以高特异性划分了c-Met阳性质瘤.
在瘤中[18F]-AZC积累和c-Met表达水平之间发现了正相关性.

结论:

[18F]-AZC是一种有前途的PET成像探头,用于c-Met.
这种新型的探测器有可能有助于癌症患者的抗c-Met疗法的管理.

关键词:

质瘤是一种质瘤.介质细胞上皮质过渡受体.在这里,PET是PET.奎诺林衍生化合物奎诺林衍生化合物 [18F]-AZCC 的时间.

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