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植物性营养药配方在体外发酵过程中调节人类肠道微生物群和酸酶活性

Saarika Pothuvan Kunnummal^1,2, Nidhi Sori¹, Mudassir Azeez Khan³

¹Department of Microbiology and Fermentation Technology, CSIR- Central Food Technological Research Institute, Mysuru, Karnataka, 570020, India.

Current microbiology

|November 8, 2023

概括

植物性营养药可以促进肠道微生物,增加酸化酶 (FAE) 和短链脂肪酸 (SCFA). 这增强了抗氧化活性,提供了一种天然的方法来对抗氧化应激.

科学领域:

微生物学微生物学
营养科学营养科学
生物化学生物化学

背景情况:

氧化应激,反应性氧物种和抗氧化防御的不平衡,有助于慢性疾病.
肠道微生物群及其代谢产物在减轻氧化应激和影响宿主代谢方面发挥着至关重要的作用.
酸乙酶 (FAE) 是关键的肠道酶,可以从植物化合物中释放酸 (FA),一种强大的抗氧化剂.

研究的目的:

研究两种植物性营养药配方 (PC1:谷物;PC2:水果蔬菜) 对肠道微生物群组成的影响.
评估这些配方对FAE,西兰酶,核酸酶和短链脂肪酸 (SCFA) 生产的影响.
评估体外发酵产品抗氧化活性所产生的变化.

主要方法:

用PC1和PC2营养药配方化的人类便样本的体外发酵.
对肠道微生物丰富性的分析,包括Bifidobacterium和Lactobacillus等关键品种.
量化FAE,西兰酶,点酶,SCFA和其他小代谢物,以及抗氧化活性测定.

主要成果:

两种PC1和PC2配方都显著增加了有益的肠道细菌 (Bifidobacterium,Lactobacillus,Prevotella,Faecalibacteria,Clostridium leptum) 的丰富性.
在两种配方的发酵后,酶生产 (FAE,西兰酶,乳酸酶) 和SCFA水平都增加了.
与PC2相比,PC1表现出更强烈的FAE和西兰酶生产刺激,导致抗氧化活性增强.

结论:

植物性营养品,特别是PC1,有效调节肠道微生物群,增加FAE和SCFA的产生.
这种调节增强了肠道的抗氧化能力,这表明这些配方在控制氧化应激方面发挥了作用.
富含FA的植物配方可以作为预防性营养补充剂,通过肠道微生物组调节来减轻氧化压力.

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