状态后后脑膜病变:结果和危险因素
Clara Marie Bode1, Simon Bruun Kristensen1, Hanne Tanghus Olsen2
1Department of Neurology, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark.
Neurocritical care
|November 8, 2023
概括
在状态 (SE) 之后,静脉后脑病变很常见,并且与生存率低下有关. 病因,镇静剂持续时间,年龄和病前状况是关键的危险因素,而不是特征.
科学领域:
- 神经学 神经学
- 关键护理医学 关键护理医学
- 神经科学是一个神经科学.
背景情况:
- 脊髓后脑病变 (PIE) 是一种已知的继状态 (SE) 之后的并发症.
- 然而,它的预后意义和具体触发因素仍然不太清楚.
- 这项研究研究了PIE的风险因素及其对患者出院后生存率的影响.
研究的目的:
- 为了确定风险因素,有助于在状态后的 postictal encephalopathy 的发展.
- 为了评估后点脑病对医院出院后长期存活率的影响.
主要方法:
- 进行了成年患者的回顾性队列研究,这些患者首次患有非毒性状态.
- 在SE停止后的14天内,使用西黑文标准 (WHC) 评估了后肠道脑病变.
- 收集了有关人口统计,临床特征,EEG,成像和重症监护的数据.
主要成果:
- 85.3%的患者至少表现出WHC 2级的直肠后脑病变.
- 排放时的WHC等级与长期存活率差 (p < 0.001) 有很强的相关性.
- 病因,镇静时间,年龄和病前的兰金度量表是脑病变严重程度的重要预测因素.
结论:
- 在SE后,静脉后脑病变很普遍,并且与长期存活率的降低有关.
- 扣押特征没有独立预测PIE.
- 潜在的病因,长时间的镇静 (例如,米达佐拉姆),晚年和不良的前发病状态是PIE发展的主要危险因素.
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