糖尿病和潜伏结核病感染:一个更新的元分析和系统审查
Guozhong Zhou1, Xin Guo2, Shunli Cai2
1Department of Science and Research, The Affiliated Anning First People's Hospital of Kunming University of Science and Technology, Kunming, 650302, Yunnan Province, China.
BMC infectious diseases
|November 8, 2023
概括
糖尿病 (DM) 与潜在结核病感染 (LTBI) 的风险更高有关. 这一元分析证实了积极的关联,强调了针对糖尿病患者群体进行有针对性的公共卫生干预的必要性.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
背景情况:
- 以前的研究表明,糖尿病 (DM) 和潜伏性结核病感染 (LTBI) 之间存在联系.
- 本研究旨在更新对DM-LTBI协会的理解.
- 为了探索这种关系,进行了系统性审查和元分析.
研究的目的:
- 对DM和LTBI之间的关联进行系统审查和元分析.
- 为DM患者提供关于LTBI风险增加的最新证据.
- 为未来的研究和公共卫生战略提供见解.
主要方法:
- 在2022年7月19日之前进行了全面的数据库搜索 (Embase,Cochrane图书馆,PubMed).
- 包括观察性研究,比较DM和非DM组的LTBI率,报告调整的赔率比率 (aOR) 或风险比率 (aRR).
- 随机效应模型用于计算95%置信区间 (CI) 的聚合估计值;研究质量使用纽卡斯尔-太华尺度进行评估.
主要成果:
- 纳入了22项涉及68256名参与者的研究.
- 在横截面研究中,聚合调整的几率比率 (aOR) 为1.21 (95% CI:1.14-1.29).
- 在横截面研究中,聚合原始几率比率 (cOR) 为1.64 (95% CI: 1.36-1.97),在队列研究中,原始风险比率 (cRR) 为1.62 (95% CI: 1.03-2.57).
结论:
- 在DM和LTBI之间存在积极的关联.
- 患有DM的个体具有较高的LTBI风险.
- 这些发现支持针对糖尿病患者的LTBI管理的有针对性的干预措施.
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