甘油三和HDL胆固醇的比率和2型糖尿病的发病率:松下队列研究10
Hiroki Yuge1, Hiroshi Okada2,3, Masahide Hamaguchi1
1Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-Cho, Kawaramachi-Hirokoji, Kamigyo-Ku, Kyoto, 602-8566, Japan.
甘油三与高密度胆固醇的比率 (TG/HDL-C) 是10年内2型糖尿病 (T2D) 发展的强有力的预测因素. 这种脂质谱提供了比单独的LDL-C,HDL-C或TG更好的预测.
科学领域:
- 内分泌学和新陈代谢学
- 心血管健康 心血管健康
- 糖尿病研究 糖尿病研究
背景情况:
- 之前的研究将高甘油与高密度脂蛋白胆固醇 (TG/HDL-C) 的比例与糖尿病发病率的增加联系在一起.
- 对比各种脂质配置文件对糖尿病发展的预测能力的注意力有限.
- 在预测糖尿病时,TG/HDL-C比率的最佳切断值需要进一步研究.
研究的目的:
- 检查TG/HDL-C比率与2型糖尿病 (T2D) 发病之间的关系.
- 为了确定T2D发病预测TG/HDL-C比的适用切断值.
- 为了比较TG/HDL-C比率与其他脂质资料的预测性能.
主要方法:
- 从2008年到2017年利用了120,613名参与者的健康检查数据库.
- 采用考克斯回归分析,对年龄,性别,BMI,血压,葡萄糖,吸烟和运动进行多变量调整.
- 使用依赖时间的接收器运行特征 (ROC) 曲线 (AUC) 评估预测性能,并使用标准标准确定T2D.
主要成果:
- 在6.0年的中位数随访期间,共发现了6080例T2D病例.
- TG/HDL-C比率与发生T2D风险有显著的相关性 (每单位HR:1.03).
- 与单独的LDL-C,HDL-C和TG (P <0.001) 相比,TG/HDL-C比率显示出优异的预测性能 (AUC=0.679,切断点=2.1在10年内).
结论:
- TG/HDL-C比率是T2D在10年内发展的更强有力的预测因素,而不是单个脂质测量.
- 这些发现表明,TG/HDL-C比率在未来的糖尿病预防医疗治疗支持中具有潜在的实用性.
- 亚组分析表明,脂质样本与T2D发病之间的相关性在女性和BMI<25 kg/m2的个体中更强.
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