端粒长度与非酒精性脂肪肝疾病之间的关联:一项前性研究
Linxi Tang1,2, Dankang Li1,2, Yudiyang Ma1,2
1Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, No.13 Hangkong Road, Wuhan, 430030, China.
BMC medicine
|November 8, 2023
概括
较长的端粒长度 (TL) 与患非酒精性脂肪肝疾病 (NAFLD) 的风险降低有关. 端粒长度也在年龄和其他因素如何影响NAFLD风险方面发挥作用.
科学领域:
- 遗传学和流行病学
- 代谢疾病 研究 研究 研究 研究
背景情况:
- 关于端粒长度 (TL) 与非酒精性脂肪性肝病 (NAFLD) 之间的联系的研究有限.
- 本研究研究了TL和NAFLD发病率之间的关系及其在已知的风险因素中的调解作用.
研究的目的:
- 检查白细胞端粒长度与发生的非酒精性脂肪肝疾病之间的关联.
- 评估端粒长度对NAFLD与年龄,空气污染,生活方式和遗传倾向等风险因素的关联的贡献.
主要方法:
- 使用定量PCR测量白细胞端粒长度.
- 为NAFLD构建多基因风险评分 (PRS),空气污染评分和生活方式指数.
- 考克斯的比例危险模型被用来估计危险比率 (HRs) 和95%置信区间.
主要成果:
- 在英国生物银行467,848名参与者中,共发现了4809例NAFLD病例,平均随访时间为12.83年.
- 较长的TL与发生NAFLD的风险降低有关 (HR每IQR增加:0.93;95%CI:0.89,0.96).
- TL部分调解了年龄与NAFLD相关性 (15.52%) 并与PRS,空气污染和生活方式相互作用,低TL加剧了风险.
结论:
- 较长的端粒长度与NAFLD发病率降低的风险有关.
- 端粒长度是影响非酒精性脂肪肝疾病发展的重要因素.
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