左乳房放射治疗中的心脏保护技术:用于例行临床决策的快速选择标准
Meltem Kirli Bolukbas1, Sibel Karaca2, Volkan Coskun3
1Department of Radiation Oncology, Health Sciences University Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Tevfik Saglam Street, Bakirkoy, 34140, Istanbul, Turkey. meltemkrl@gmail.com.
European journal of medical research
|November 8, 2023
概括
预测因素,如左肺体积可以识别患者需要心脏节约性放射治疗左乳腺癌,潜在地减少不必要的呼吸门治疗.
科学领域:
- 在瘤学瘤学.
- 放射治疗 物理 物理
背景情况:
- 在左乳房放射治疗 (RT) 中达到最佳的心脏剂量对于最大限度地减少心脏毒性至关重要.
- 对于一些患者来说,传统的RT技术可能足够,但确定那些从节省心脏的技术中获益最多的人是必不可少的.
研究的目的:
- 确定预测因素和特定的切断点,以确定患者在左乳腺癌中符合心脏节约性放射治疗的资格.
- 通过根据患者在没有先进技术的情况下实现目标心脏剂量的可能性进行分层来优化RT规划.
主要方法:
- 从114名接受RT的左乳癌患者的剂量测量数据的回顾性分析.
- 用接收器操作特征 (ROC) 分析来评估预测因素,包括左肺体积和肺/心脏体积比率.
- 使用SPSS软件进行了统计分析.
主要成果:
- 左肺体积是乳房保护手术 (BCS) 病例的重要预测因素 (AUC:0.74).
- 在乳腺切除的情况下,左肺体积 (AUC:0.81) 和肺/心体积比率 (AUC:0.83) 都是心脏剂量相关性的显著预测指标.
- 确定了具体的切断点:BCS中左肺体积为1154cc,乳腺切除术中左肺体积为1208cc,乳腺切除术患者的肺/心体积比为1.92.
结论:
- 对于左肺体积和肺/心体积比的确定的切断点可以预测在左乳房RT中需要节省心脏的技术.
- 利用这些切断点可以帮助从耗时的呼吸控制方法中删除大量患者 (BCS高达70%,乳腺切除40%) 的选择.
- 肺体积和肺/心体积比低于确定的值的患者是先进的心脏节省RT技术的主要候选人.
相关概念视频
Imaging Studies for Cardiovascular System III: X-Ray
193
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
193
Radiological Investigation III: Pulmonary Angiogram and PET Scan
97
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
97
Cardiac Catheterization III: Left Heart Catheterization
21
Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
21
Imaging Studies for Cardiovascular System V: CT
21
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
21


