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从对化学抗原受体T细胞免疫疗法在癌症中的单细胞分析中获得的见解

Lu Tang1,2,3, Zhong-Pei Huang1,2,3, Heng Mei4,5,6,7

  • 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Military Medical Research
|November 8, 2023
PubMed
概括

单细胞测序揭示了对仿真抗原受体 (CAR) -T细胞治疗失败和成功的见解. 这项技术有助于优化CAR-T细胞设计和制造,以改善血液恶性瘤患者的治疗结果.

关键词:
在CAR-T疗法中,癌症免疫疗法癌症免疫疗法细胞异质性 细胞异质性单细胞测序是一种单细胞测序.轨迹推断的推理方法瘤微环境是一个微环境.

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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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