脊椎手术后的化学预防性抗凝药不增加外周血瘤风险:一种倾向匹配分析
Michael B Cloney1, Ekamjeet Dhillon, Benjamin Hopkins
1Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL.
Clinical spine surgery
|November 9, 2023
概括
化疗预防性抗凝剂并没有增加脊柱手术后外周血液瘤 (EDH) 的风险. 这项研究发现,在接受脊柱手术的患者中,化疗预防和EDH发展之间没有显著的关联.
科学领域:
- 神经外科 神经外科
- 整形外科手术 整形外科手术
- 麻醉学 麻醉学
背景情况:
- 化疗预防用于预防脊椎手术后静脉血栓栓塞事件.
- 有一种潜在的担忧是,抗凝固药可能会增加外周血液瘤 (EDH) 的风险.
研究的目的:
- 为了确定化疗预防性抗凝药是否会增加脊椎手术后患上外周血液瘤 (EDH) 的风险.
- 量化化疗和术后EDH之间的关联.
主要方法:
- 一项对6869次脊柱手术的回顾性队列研究.
- K-最近邻居倾向得分匹配被用来比较接受化疗预防的患者与对照者.
- 确定了在术后30天内撤离的有症状的EDH.
主要成果:
- 在匹配后,1071名接受化疗预防的患者与1585名对照人群进行了比较.
- 在接受化疗预防的患者中,没有发现EDH率显著增加 (P=0.294).
- EDH独立地与输血,胸部手术和更高的体重指数有关.
结论:
- 在这种患者群体中,化疗预防性抗凝剂似乎不会增加脊髓外周血瘤的发生率.
- 这些发现表明,用于预防静脉血栓栓塞的化学预防的好处超过了脊椎手术患者EDH的风险.
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