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相关概念视频

Next-generation Sequencing03:00

Next-generation Sequencing

89.0K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
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Amino Acid Biosynthetic Pathways01:29

Amino Acid Biosynthetic Pathways

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Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which...
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C4 Pathway and CAM01:27

C4 Pathway and CAM

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Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
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Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

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Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
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Protein Networks02:26

Protein Networks

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A Web Tool for Generating High Quality Machine-readable Biological Pathways
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维基路径2024:下一代路径数据库

Ayushi Agrawal1, Hasan Balcı2, Kristina Hanspers1

  • 1Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, 94158, USA.

Nucleic acids research
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PubMed
概括
此摘要是机器生成的。

开源生物路径数据库WikiPathways已经重组,以提高用户体验和可维护性. 这种演变通过改进的功能和自动化来支持社区策划和科学合作.

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科学领域:

  • 生物信息学是一种生物信息学.
  • 系统生物学 系统生物学
  • 计算生物学 计算生物学

背景情况:

  • 维基路径是生物路径信息的重要开源资源.
  • 社区合作和开放科学是其成长和成功的基础.
  • 数据库面临着与大规模数据策划固有的不断变化的技术挑战.

研究的目的:

  • 详细介绍最近在WikiPathways中取得的进展,以支持其持续的增长和合作.
  • 概述为确保未来的稳定性和可维持性而进行的重大重组.
  • 突出用户体验和社区参与功能方面的改进.

主要方法:

  • 主要的网站重新设计和后端重组.
  • 实施新的功能,以促进社区的投入.
  • 利用自动化来提高数据库的维护能力和策划能力.

主要成果:

  • 通过重新设计的网站增强了用户体验.
  • 提高生物通路数据库的稳定性和可维护性.
  • 新功能使社区参与和投入更大.

结论:

  • 经过重组的WikiPathways平台准备好迎接未来的增长和持续的社区策划.
  • 增强的技术基础设施和以用户为中心的设计加强了它在生物研究中的作用.
  • 对开放科学原则的持续承诺确保了它对科学界的价值.