在澳大利亚使用抗精神病药物的标签和非标签使用 (2000-2021):对两种药物数据集的回顾性分析
Ramya Padmavathy Radha Krishnan1, Christopher Harrison2, Nicholas Buckley1,3
1Biomedical Informatics and Digital Health, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
The Australian and New Zealand journal of psychiatry
|November 9, 2023
概括
澳大利亚成年人使用抗精神病药物从2005年至2021年增加,其中27%的处方是针对抑郁症和焦虑症等疾病的非标签处方. 这一趋势需要加强监测,因为潜在的不良影响.
科学领域:
- 药物监督和药物流行病学
- 公共卫生和卫生服务研究研究
背景情况:
- 抗精神病药物被广泛使用,但人们对其长期安全性和适当的处方存在担忧.
- 了解澳大利亚抗精神病药物使用模式,包括标签上和标签外使用,对于患者安全和医疗保健政策至关重要.
研究的目的:
- 调查2005年至2021年澳大利亚成年人的抗精神病药物处方趋势.
- 区分标签上和标签之外的抗精神病药物使用,并确定相关的患者和处方特征.
主要方法:
- 利用药品福利计划 (PBS) 数据集的10%样本用于发行数据 (2005-2021).
- 补充了改善健康评估和护理 (BEACH) 数据集 (2000-2016) 以确定处方诊断指示.
- 分析了发病率,流行率和常见抗精神病药物发行的趋势,以及非标签处方率.
主要成果:
- 观察到抗精神病药物发行发生率和流行率的稳步增加,主要是由口服第二代抗精神病药物驱动的.
- 奎蒂亚平,奥兰扎平和瑞斯佩里是最常使用的抗精神病药物.
- 分析显示,27%的抗精神病药物处方用于非标签性适应症,通常是较低剂量的,包括抑郁症,痴呆症,焦虑症和失眠症.
结论:
- 抗精神病药物处方的上升趋势,特别是非标签使用,引发了对潜在的慢性不良影响的担忧.
- 对发行数据和诊断指示的综合分析为药物使用提供了新的见解.
- 强调在临床实践中加强对抗精神病药物的监测至关重要.
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