血管接入自主外周血液干细胞采集大体积白血病:单一中心体验经验
Ines Bojanić1,2,3, Greta Novosel1,3, Marijana Lukač Baričević1
1Department of Transfusion Medicine and Transplantation Biology, University Hospital Center Zagreb, Zagreb, Croatia.
Journal of clinical apheresis
|November 9, 2023
概括
外周静脉接入 (PVA) 是一项安全有效的选择,超过一半的患者接受自身外周血液干细胞 (PBSC) 采集,特别是多发性骨髓瘤患者. 这种方法避免了中央静脉导管 (CVC),而不会影响收集效率或安全.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学 移植医学
- 血管接入 血管接入
背景情况:
- 外周血液干细胞 (PBSC) 采集需要可靠的血管接入.
- 实践中的转变是从例行中央静脉导管 (CVC) 放置到对自主PBSC采集的单个外周静脉接入 (PVA) 评估.
研究的目的:
- 为了确定PVA对自主PBSC采集的可行性.
- 为了比较PVA和CVC组之间的患者特征,收集效率和并发症.
主要方法:
- 围静静脉的前性评估由自主PBSC采集的异位护士进行.
- CVC插入只适用于难以进入静脉的病例.
- 采用大体积白血病 (LVL) 处理 ≥3 个总体血液体积.
主要成果:
- 在57%的患者中使用PVA;在43%的患者中需要CVC.
- 与淋巴瘤患者 (33.3-35.9%) 相比,男性 (69.8%) 和多发性骨髓瘤患者 (71.0%) 的PVA成功率更高.
- 在没有细胞静止剂 (75.0%) 接受化疗的患者中,PVA更频繁;在PVA和CVC之间,LVL的疗效和安全性是可比的.
结论:
- 在超过一半的患者中,PVA是自主PBSC采集的可行选择,特别是那些患有多发性髓瘤的患者.
- 现代多发性骨髓瘤治疗保留了周围静脉,使PVA即使在高流量LVL手术中也可行.
- PVA是安全的,高效的,具有成本效益的,并且需要经验丰富的非瑞斯团队进行个性化评估.
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