炎症性肠病的现实世界持久性 生物学使用患者登记数据
Tia Goss Sawhney1,2, Angela Dobes3, Sirimon O'Charoen3
1Teus Health, LLC, Newark, NJ, USA.
Crohn's & colitis 360
|November 9, 2023
概括
在炎症性肠病 (IBD) 中,现实世界生物药物持续性可通过患者登记册进行跟踪. 大多数患者至少持续使用生物药物三年,为医疗保健提供了宝贵的见解.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 在现实世界中,药物使用的持续性和停止性,特别是昂贵的生物疗法,仍未得到充分研究.
- 了解药物坚持是至关重要的,因为药物只有在持续服用时才能使患者受益.
研究的目的:
- 评估收集患者报告的炎症性肠病 (IBD) 中药物持续性数据的可行性.
- 分析IBD患者生物疗法的现实药物使用持久性和停止模式.
主要方法:
- 利用IBD合作伙伴患者登记处的纵向,自我报告的药物使用数据.
- 构建了Kaplan-Meier药物使用持久度图表,用于2017年至2022年间开始使用的生物药物使用跨度.
- 从1594名调查参与者中分析了2034个药物使用跨度.
主要成果:
- 大多数生物药物在一年后表现出超过75%的持续性,在三年后表现出超过60%的持续性.
- 观察到的整体药物持久性和药物间变异与现有文献一致.
- 通过自愿登记,确认收集患者报告的药物持续性数据的可行性.
结论:
- 患者报告的数据为药物持续性和停药原因提供了独特的现实洞察力,补充了传统数据来源.
- 这种方法为医生,患者,付款人,决策者和卫生技术评估组织提供了有价值的观点.
- 患者登记是一个可行的方法,用于收集关键的现实世界证据,以证明IBD的生物药物坚持.
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