同源性带组织用于关节损伤
Adarsh Aratikatla1, Samir Ghandour2, Nicola Maffulli3,4,5,6
1The Royal College of Surgeons in Ireland, Dublin, Ireland.
Frontiers in pain research (Lausanne, Switzerland)
|November 9, 2023
概括
来自带衍生物的人类干细胞在再生关节 (TMJ) 组织方面表现有前途. 需要进一步的研究来证实这一再生医学方法对关节疾病的安全性和有效性.
科学领域:
- 再生医学是一种再生医学.
- 整形外科 整形外科 整形外科
- 干细胞生物学 干细胞生物学
背景情况:
- 关节 (TMJ) 疾病会影响和关节.
- 常见的肌关节问题包括骨关节炎,内部乱和肌关节疼痛.
- 目前的治疗方法从保守疗法到外科手术.
研究的目的:
- 系统地审查有关带 (UC) 衍生组织和中干细胞 (MSCs) 治疗关节疾病的文献.
- 评估同源获得的UC衍生MSCs对TMJ疾病的安全性和有效性.
- 确定当前研究中的差距,并建议未来的方向.
主要方法:
- 在PubMed,Embase,Scopus和Web of Science数据库中进行系统的文献搜索.
- 遵守PRISMA指导方针进行研究选择.
- 包括体外,临床前和临床研究,以及临床试验注册表.
主要成果:
- 确定了报告UC衍生组织和MSC的安全性和有效性的研究.
- 突出了这些全基细胞来源在TMJ组织再生中的潜力.
- 承认需要更强大的临床数据.
结论:
- 带衍生中干细胞代表了关节疾病的有前途的非手术治疗选择.
- 全基性UC衍生组织和MSCs显示了关节组织再生的潜力.
- 进一步提供足够的动力,随机对照试验对于验证临床使用至关重要.
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