咖啡消费和老年人全因和心血管死亡率:我们应该考虑认知功能吗?
Fabin Lin1,2,3,4, Yisen Shi1,2,3, Xinyang Zou1,2,3
1Department of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, Fuzhou, China.
Frontiers in nutrition
|November 9, 2023
概括
咖啡消费可能会降低死亡风险,特别是在认知障碍的老年人中. 无咖啡因咖啡在这个群体中也显示了降低死亡率的好处.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 老年学是指老年学的学科.
背景情况:
- 以前的研究将咖啡消费与死亡风险和认知功能联系起来.
- 研究还缺乏关于认知功能如何影响咖啡与死亡率的关联.
研究的目的:
- 调查咖啡,咖啡因和无咖啡因咖啡与老年人全因和心血管疾病 (CVD) 死亡率的关联.
- 检查不同水平的认知表现如何改变这些关联.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 2011-2014年数据.
- 通过24小时饮食回忆评估咖啡/咖啡因摄入量.
- 使用CERAD-word学习测试 (CERAD-WLT),动物流利性测试 (AFT) 和数字符号替代测试 (DSST) 评估认知功能,以及从主要组件分析 (PCA) 获得的全球认知得分.
- 采用考克斯回归和受限立方线 (RCS) 分析.
主要成果:
- 没有喝咖啡的认知障碍患者的死亡风险最高.
- 在AFT,DSST和全球认知的认知障碍患者中,咖啡消费与全因死亡率有显著的负相关性.
- 在CERAD-WLT中观察到咖啡消费与死亡率之间存在U形关联.
- 脱咖啡因咖啡的消费与认知障碍参与者的死亡率降低有关.
结论:
- 咖啡消费与死亡率之间的关联受认知状态的影响.
- 咖啡对死亡率的影响在不同的认知领域和障碍水平上有所不同.
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