发生率和临床影响的硬化肌病特异性自身抗体在血清阴性患者与Sicca投诉
Nikolaos Marketos1, Clio P Mavragani1,2
1Department of Physiology, Medical School of Athens, National and Kapodistrian University of Athens, Athens, Greece.
Mediterranean journal of rheumatology
|November 9, 2023
概括
系统性硬化症特异性自身抗体普遍存在于对Ro/SSA和La/SSB抗体负的西卡症状患者中. 这一发现强调了对这一患者群体进行更密切的监测和向治疗的必要性.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 这是一种自身免疫力.
背景情况:
- 斯约格伦综合征 (SS) 患者经常表现出反中心抗体,特别是对Ro/SSA和La/SSB的血清阴性.
- 患有系统性硬化症 (SSc) 病情的血清阴性患者中系统性硬化症 (SSc) 特定自身抗体的存在和临床相关性仍未得到充分研究.
研究的目的:
- 为了确定SSc特异性自身抗体在患有西卡症状但抗Ro/SSA和抗La/SSB抗体检测阴性的患者中的患病率.
- 在这个患者队列中调查这些SSc特定自身抗体的临床意义.
主要方法:
- 在51名患者中,使用EUROLINE系统性硬化症 (核细胞) 档案 (IgG) 进行了13种SSc特异性自身抗体的血清测试.
- 对这些患者收集了人口统计,临床和实验室数据.
- 患者从一个更大的队列中选择,包括212名被调查Sicca症状的个人.
主要成果:
- 在评估的血清阴性西卡患者中,在57% (29/51) 的患者中检测到SSc特异性自身抗体.
- 确诊的特定抗体包括NOR90,Th/To,Ku,Ro52,CENP-B,CENP-A,RP155,RP11,PM/Scl 75,Scl70,PM/Scl 100和纤维素.这些抗体可以被认为是最常见的抗体.
- 这些患者的一小部分患者后来患上肺高血压和间歇性肺病.
结论:
- 血清阴性西卡患者中SSc特异性自身抗体的高患病率表明,存在潜在的SSc风险亚群.
- 这些自身抗体的鉴定需要更密切的跟踪和系统的管理策略.
- 这项研究强调了在Sicca患者中进行全面的自身抗体查的重要性,这些患者对常见的SS相关抗体呈阴性.
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