在类风湿性疾病中补充脱氨 (DHEA):系统性审查
Thelma L Skare1, Elizabeth Hauz2, Jozélio Freire de Carvalho3
1Rheumatology Unit, Hospital Evangélico Mackenzie, Curitiba, PR, Brazil.
Mediterranean journal of rheumatology
|November 9, 2023
概括
脱氨 (DHEA) 显示出治疗系统性红斑狼 (SLE) 的前景,改善骨密度和疾病活性. 它在类风湿性关节炎 (RA),Sjogren综合征 (SS) 和纤维肌痛 (FM) 的有效性仍然不确定.
科学领域:
- 类风湿病学 类风湿病学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 脱氨 (DHEA) 是一种上腺激素,研究用于治疗类风湿性疾病.
- 它在全身性红斑狼 (SLE),肖格伦综合征 (SS) 和类风湿性关节炎 (RA) 的疗效产生了有争议的结果.
研究的目的:
- 系统地审查关于DHEA在各种类风湿性疾病中的治疗作用的现有文献.
主要方法:
- 在PubMed,Scielo,Scopus和Embase数据库中进行了全面的搜索.
- 包括在1966年至2023年4月之间发表的关于DHEA治疗风湿性疾病的文章.
主要成果:
- 在SLE的13项研究表明,疾病活动,骨矿物质密度 (BMD) 和疲劳的轻度到中度改善.
- 对SS的研究显示了一些症状缓解,但在疾病活性方面与安慰剂没有显著差异.
- 在RA和纤维肌痛中,有限的证据表明疾病活动的改善值得怀疑或没有改善.
结论:
- DHEA在SLE治疗中显示出潜在的益处,特别是在骨损伤和疾病控制方面.
- 由于不确定的发现,DHEA在RA,SS和纤维肌痛中的治疗作用需要进一步调查.
相关概念视频
Rheumatic Heart Disease III: Medical Management
11
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
11
Rheumatic Heart Disease IV: Nursing Management
14
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
14
Rheumatic Heart Disease I: Introduction
14
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
14
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
37
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
37


