在具有较低背景死亡率的地区,高或低氧和目标的类似不良结果率
Nina Willgerodt1, Christoph Bührer2, Rainer Rossi3
1Division of Neonatology, University Hospital for Children, Leipzig, Germany.
Frontiers in pediatrics
|November 9, 2023
概括
在极度早产婴儿中,较低的氧和目标并没有增加安全风险. 这项回顾性研究发现,高氧和和低氧和组之间的早产死亡率或视网膜病变没有显著差异.
科学领域:
- 新生儿重症监护中心
- 儿科医学 儿科医学
- 临床研究 临床研究
背景情况:
- 随机试验表明,在非常早产的婴儿中,高氧和目标的死亡率较低.
- 高氧和与早产性视网膜病变和支气管肺功能失调的增加有关.
- 氧和目标的益处与危害的比率可能随着当地死亡风险而有所不同.
研究的目的:
- 量化不同氧和度 (SpO2) 目标范围的风险效益比.
- 评估东德10个新生儿重症监护病房 (NICU) 的SpO2目标.
主要方法:
- 一项对1399名婴儿 (2008-2012) 的回顾性多中心研究.
- 婴儿出生于24 0/7至27 6/7周的妊娠年龄,出生体重<1,250g.
- 按高 (HOSG,>90%) 和低 (LOSG,<90%) 的SpO2目标范围和单位合规性分组.
主要成果:
- 五个NICU是HOSG,五个是LOSG;九个达到他们的目标.
- 死亡性肠球炎和严重的腹腔内出血在HOSG中更频繁.
- 两组之间死亡率或早产率的视网膜病变没有显著差异.
结论:
- 在这一群体中,较低的SpO2目标范围与安全风险的增加无关.
- 研究的局限性包括回顾性设计和现场实践的变化,排除了明确的因果关系.
关键词:
支气管肺功能失育症 支气管肺功能失育症腹腔内出血 腹腔内出血死亡率 死亡率死性肠球炎 (necrotizing enterocolitis) 是一种致死性肠球炎.氧气的困境 氧气的困境氧气和和氧气和的情况.早产婴儿早产婴儿过早生育的视网膜病变更多相关视频
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