海马缩与认知正常的成年人听力损失有关
Ye Ji Shim1,2, Wi Hoon Jung3, Alexander J Billig4
1Department of Otorhinolaryngology-Head and Neck Surgery, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea.
Frontiers in neuroscience
|November 9, 2023
概括
听力损失与海马体灰色质量减少有关. 这项针对老年人的研究表明,听力障碍可能会导致海马缩.
科学领域:
- 神经科学是一个神经科学.
- 听力学 听力学是指听力学.
- 老年学是一门学科.
背景情况:
- 与年龄相关的听力损失 (HL) 越来越多地与大脑变化有关.
- 之前对HL和大脑皮层形态学的研究使用了有限的数据.
- 调查HL和灰色物质体积 (GMV) 之间的相关性需要更大的样本大小和偏差控制.
研究的目的:
- 在一个大群体中检查听力值和GMV之间的关系.
- 评估听力损失严重程度组之间的GMV差异.
- 探索可能导致老化过程中大脑结构变化的因素.
主要方法:
- 追溯分析405个认知正常的老年人,听力测量和MRI数据.
- 基于voxel的形态测量用于评估GMV.
- 共同变量包括年龄,性别,教育,K-MMSE和医疗条件.
主要成果:
- 在听力值和海马GMV之间发现了显著的负相关性.
- 与正常听力 (NH) 和轻度听力损失 (MHL) 组相比,中度至重度听力损失 (MSHL) 组显示出明显较低的左海马体GMV.
结论:
- 周边分离可能会导致老年人海马缩.
- 听力损失与大脑结构变化有关,特别是在海马体.
- 进一步的研究是有必要的,以了解链接HL和大脑形态的机制.
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