催眠使用与慢性阻塞性肺部疾病和失眠患者的全因死亡率之间的关联
Ali A El-Solh1,2,3, Yolanda Lawson1, Gregory E Wilding4
1Research Department, VA Western New York Healthcare System, Buffalo, NY, USA.
International journal of chronic obstructive pulmonary disease
|November 9, 2023
概括
慢性阻塞性肺病 (COPD) 和失眠患者的催眠使用与更高的死亡风险有关. 二二胺受体激动剂 (BZRAs) 显示死亡风险显著增加.
科学领域:
- 医学研究 医学研究
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 失眠是慢性阻塞性肺病 (COPD) 患者的常见问题.
- 催眠药物经常被处方用于COPD患者的失眠.
- 这些药物带有重大潜在风险.
研究的目的:
- 评估COPD和失眠的退伍军人中催眠药物使用和全因死亡率之间的关联.
- 在这个特定的患者群体中量化与催眠处方相关的死亡风险.
主要方法:
- 使用了回顾性队列研究设计.
- 数据来源于退伍军人健康管理公司数据仓库,与医疗保险,医疗补助和国家死亡指数记录 (2010-2019) 相联系.
- 倾向性得分1:1匹配用于控制催眠使用者和非使用者之间的基线差异.
主要成果:
- 该研究包括5759名COPD退伍军人;3585人开始使用催眠. 在平均7.4年的随访期间,发生了2301例死亡.
- 催眠使用与全因死亡风险增加22%有关 (HR 1.22;95% CI,1.11-1.35).
- 二二胺受体激动剂 (BZRAs) 显示出较高的死亡率 (IRR 1.27; 95% CI, 1.14-1.43),而非BZRA催眠剂在2年后没有显著增加.
结论:
- 患有失眠的COPD患者的催眠治疗与所有原因死亡率的风险增加有关.
- 这种增加的风险特别明显在使用二二胺受体激动剂 (BZRAs) 时.
- 这些发现表明一个类效应,非BZRAs随着时间的推移显示中度风险.
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