在急性A型大动脉剖析呈现时,胸前大动脉直径的男性和女性差异
F Meccanici1, A W Bom1, W G Knol2,3
1Department of Cardiology, Erasmus University Medical Centre, Rotterdam, Netherlands.
International journal of cardiology. Heart & vasculature
|November 9, 2023
概括
患有急性A型大动脉解剖 (ATAAD) 的女性患者的上升大动脉直径比男性更大. 这一发现表明,在ATAAD中,与性别相关的疾病表现或患者选择可能存在差异.
科学领域:
- 心血管研究的心血管研究.
- 胸部外科手术 胸部外科手术
- 医学成像医学成像
背景情况:
- 急性A型大动脉解剖 (ATAAD) 是一种危及生命的疾病,通常涉及大动脉扩张.
- 在ATAAD中,患者身高,体重和性别对胸前大动脉直径 (TAA) 的影响尚不清楚.
研究的目的:
- 在患有ATAAD的患者中调查胸前大动脉直径 (TAA) 的基于性别的差异.
- 为了确定患者的性别是否与ATAAD中的大动脉尺寸有关.
主要方法:
- 来自两个三级中心的成年ATAAD患者 (2007-2017) 的回顾性横截面研究.
- 对比增强型计算机断层扫描 (CTA) 扫描分析绝对和索引的大动脉直径 (瓦萨尔瓦鼻腔,上升大动脉,下降胸前大动脉).
- 使用Campens公式计算Z-分数来评估与正常值相对的大动脉尺寸.
主要成果:
- 与男性相比,女性ATAAD患者年龄较大,绝对上升大动脉直径显著更大.
- 女性表现出更大的指数大动脉直径 (ASI,AHI) 和更高的Valsalva鼻腔和上升大动脉的Z-分数.
- 在调整了临床因素后,女性性别仍然独立地与更大的最大胸前大动脉直径有关.
结论:
- 患有ATAAD的女性患者的绝对上升大动脉直径比男性大.
- 这些性别差异可能表明不同的疾病进展时间或反映患者群体的选择偏差.
- 对大动脉壁生物学和生长模式进行进一步的翻译性研究是有必要的,以解释这些观察到的性别差异.
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