口服抗凝药在患有心房高频发作患者:关注临床影响
Smaro Dimou1,2, Vasiliki C Mystakidi3, Sotirios Chiotis2
1First Department of Cardiology, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Cureus
|November 9, 2023
概括
在心房高频发作 (AHREs) 的患者中,口服抗凝剂 (OAC) 治疗没有显著改变血栓栓塞或出血事件的风险. 监测患者的特征和AHRE持续时间是管理这些人的关键.
科学领域:
- 心脏病学 心脏病学
- 临床电生理学 临床电生理学
- 血栓形成研究研究
背景情况:
- 高频率心房发作 (AHREs) 与心房动 (AF) 和血栓栓塞事件的风险增加有关.
- 尚不清楚AHREs的确切临床意义及其对缺血和出血事件的影响.
- 对于风险分层来说,研究口服抗凝剂 (OAC) 在AHREs患者中的作用至关重要.
研究的目的:
- 确定OAC启动对AHREs患者缺血和出血事件的临床影响.
- 评估OAC在治疗AHREs患者中的有效性和安全性.
- 为了确定影响OAC治疗的AHRE患者事件发生的因素.
主要方法:
- 分析了154名通过心脏植入式电子设备 (CIED) 识别的AHREs患者的研究队列.
- 患者被分为两组:开始接受OAC的患者和没有接受OAC的对照组.
- 主要终点是第一个血栓塞栓事件发生的时间,评估无血栓塞栓事件生存率.
主要成果:
- 总共154名患者 (每组77人),平均年龄为72.5岁,被跟踪了大约19个月.
- 血栓栓塞栓事件发生在7名患者中 (OAC组1名,对照组6名;P=0.05).
- 在5名患者中观察到重大出血事件 (对照组1名,OAC组4名;P=0.17).
结论:
- 在患有AHREs的患者中,OAC治疗没有显示出血栓栓塞或出血事件风险的统计学上显著差异.
- 患者的基线特征和AHRE持续时间可能指导加强监测和管理策略.
- 在OAC的AHRE患者中发生的出血事件可能表明潜在的癌症,需要进一步调查.
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